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Title:Advances in Antiviral Drug Design, Volume 5
Format Type:Ebook
Author:
Publisher:Elsevier Science & Technology
ISBN:0080548245
ISBN 13:
Number of Pages:264
Category:Manga

Advances in Antiviral Drug Design, Volume 5 by E. De Clercq

PDF, EPUB, MOBI, TXT, DOC Advances in Antiviral Drug Design, Volume 5 Regularly reviewing the state of the art developments in the antiviral drug research field this latest volume spans the conceptual design and chemical synthesis of new antiviral compounds It discusses their structure activity relationship mechanism and targets of action pharmacological behavior antiviral activity spectrum and therapeutic potential for clinical use

  • Advances in Antiviral Drug Design

    This book Download ePub PDF Free Libs - Advances in Antiviral Drug Design - Regularly reviewing the state of the art developments in the antiviral drug research field this latest volume spans the conceptual design and chemical synthesis...

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  • Advances in Antiviral Drug Design

    This book Download ePub PDF Free Libs - Advances in Antiviral Drug Design - Volume of i Advances in Antiviral Drug Design i is keeping up with the recent progress made in the field of antiviral drug research and highlights five specific...

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  • Advances in Antiviral Drug Design, Volume 2

    This book Download ePub PDF Free Libs - Advances in Antiviral Drug Design, Volume 2 - The purpose of the series on Advances in Antiviral Drug Design is to regularly review the state of the art on emerging new developments in the antiviral drug re...

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  • Advances in Antiviral Drug Design, Volume 5

    This book Download ePub PDF Free Libs - Advances in Antiviral Drug Design, Volume 5 - Regularly reviewing the state of the art developments in the antiviral drug research field this latest volume spans the conceptual design and chemical synthesis...

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  • Advances in Antiviral Drug Design, Volume 4

    This book Download ePub PDF Free Libs - Advances in Antiviral Drug Design, Volume 4 - The fourth volume of Advances in Antiviral Drug Design is keeping up with the recent progress made in the broad field of antiviral drug research and encompasses...

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  • Handbook of Viral Bioterrorism and Biodefense

    This book Download ePub PDF Free Libs - Handbook of Viral Bioterrorism and Biodefense - The atrocities of September and the more recent casualties due to anthrax bioterrorism have dramatically emphasized the potential danger of biological warfare a...

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  • Advances In Antiviral Drug Design, Volume 1

    This book Download ePub PDF Free Libs - Advances In Antiviral Drug Design, Volume 1 - The purpose of the series Advances in Antiviral Drug Design is to regularly provide an account on the chemistry of the new antiviral agents whether licensed or ...

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Advances in Antiviral Drug Design, Volume 2, Advances in Antiviral Drug Design, Volume 5, Studies in Health Technology and Informatics, Volume 141: Collaborative Patient Centered eHealth, Handbook of Viral Bioterrorism and Biodefense, Advances in Antiviral Drug Design, Advances in Antiviral Drug Design, Advances in Antiviral Drug Design, Volume 4, Advances In Antiviral Drug Design, Volume 1
The fourth volume of Advances in Antiviral Drug Design is keeping up with the recent progress made in the broad field of antiviral drug research and encompasses six specific directions that have opened new avenues for the treatment of HIV and other virus infections br First as the introductory chapter the different new anti HIV agents that are now in preclinical or clinical development are reviewed by E De Clercq This includes new NRTIs NNRTIs and PIs but also HIV entry fusion inhibitors as well as integrase inhibitors and some of these agents such as the NRTI emtricitabine FTC and the PI atazanavir may soon be licensed for clinical use br Second high expectations are vested in the potential therapeutic usefulness of inhibitors of HIV integration a point of no return in the life cycle of HIV and this approach is highlighted by D J Hazuda and S D Young br Third as all currently available PIs can be described as peptidomimetic and therefore expected to demonstrate overlapping virus drug resistance and side effect profiles it would be interesting to see how a non peptidic protease inhibitor such as tipranavir behaves and this is covered by D Mayers K Curry V Kohlbrenner and S McCallister br Fourth neuraminidase inhibitors such as zanamivir that has to be inhaled and oseltamivir that can be administered via the oral route have gained a definitive status as antiviral drugs useful for both therapy and prophylaxis of influenza A and B virus infections as they target a specific influenza viral enzyme neuraminidase or sialidase they may be expected to block newly emerging influenza viruses as well and the design of neuraminidase inhibitors has received due attention of H Jin and C U Kim br Fifth while the major current efforts in antiviral drug development have shifted from herpesviruses towards HIV and hepatitis viruses hepatitis B virus HBV hepatitis C virus HCV it is interesting to note that by switching from the classical five membered sugar or acyclic nucleoside strategy J Wang M Froeyen and P Herdewijn have gone upstream in designing six membered carbocyclic nucleosides as potential anti herpesvirus agents br Sixth following up on the nucleotide prodrug strategy introduced above under ix to deliver the biologically active nucleotides inside the cells C Meier has elaborated on a particular class of such pronucleotides namely that of the cyclosaligenyl pronucleotides an approach that should have far reaching implications for compounds effective against HIV HBV and other viruses br The six topics covered in this fourth volume of Advances in Antiviral Drug Design are in the front line of the present endeavors towards the design and development of new therapeutic agents for virus infections They pertain to the combat against three of the most important viral pathogens of current times HIV HBV influenza virus and herpesviruses, The atrocities of September and the more recent casualties due to anthrax bioterrorism have dramatically emphasized the potential danger of biological warfare and bioterrorism The editors of Antiviral Research have taken the initiative to edit a special issue of the Journal focusing on Viral Bioterrorism and Biodefense It is the first time in history that a special volume has been dedicated to this topic which in view of the current circumstances is timely appropriate and relevant To what extent could viruses be weaponized i e turned into biological weapons and used for biowarfare which viruses would lend themselves for this purpose how should we estimate the risk and the consequences which diagnostic measures should be taken and how should we react prophylactically and if needed therapeutically br, No description available, Regularly reviewing the state of the art developments in the antiviral drug research field this latest volume spans the conceptual design and chemical synthesis of new antiviral compounds It discusses their structure activity relationship mechanism and targets of action pharmacological behavior antiviral activity spectrum and therapeutic potential for clinical use